Safety First! Careers in Drug Safety and Toxicology
نویسندگان
چکیده
منابع مشابه
Flow Cytometry in Preclinical Toxicology/safety Assessment
The primary departmental goal of preclinical toxicology (a.k.a. safety assessment) in drug development is to identify and characterize drug-induced toxicity in test animals by using appropriate animal models. This is accomplished through a large number of individual studies, sometimes referred to as a “tox package,” designed to provide specific data on the pharmacology/toxicology of the drug ca...
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MIKULA P., SVOBODOVÁ Z., SMUTNÁ M. (2005): Phthalates: toxicology and food safety – a review. Czech J. Food Sci., 23: 217–223. Phthalates are organic substances used mainly as plasticisers in the manufacture of plastics. They are ubiquitous in the environment. Although tests in rodents have demonstrated numerous negative effects of phthalates, it is still unclear whether the exposure to phthala...
متن کاملSafety First and Ambiguity
There is considerable empirical evidence suggesting that ambiguity (i.e., parameter risk) impacts pricing decisions by actuaries and underwriters and their desire to provide coverage. Stone proposed a safety first model of choice that provides a possible explanation for this behavior. This paper analyzes Stone's proposed stability and survival constraints and compares the results with those pre...
متن کاملAn analysis of the use of dogs in predicting human toxicology and drug safety.
Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive d...
متن کاملAn analysis of the use of animal models in predicting human toxicology and drug safety.
Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensiv...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 1095-9203
DOI: 10.1126/science.opms.r0900068